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Safety

Toxicity

OxymaPure HOBt
GHS classification of OxymaPure is Category 4 of acute toxicity (LD50 of 300-2000mg/kg)Hydrazine used in manufacturing of HOBt is highly toxic and readily absorbed by oral, dermal or inahalation exposure. Long-term studies with laboratory animals indicate that hydrazine is mutagenic and carcinogenic. Hydrazine traces are usually present in commercial batches of HOBt ( reference)
Acute dermal irritation: In consideration of calculated Primary Irritation index, OxymaPure is categorized as a “Slight” dermal irritant.
Nitrozamine safety.
OxymaPure is made by nitrosation of ethyl 2-cyanoacetate, in the presence of sodium nitrite, however manufacturing procedure exclude formations of Nitrosamines during the synthesis which is confirmed by analytical testing.

Explosiveness/ flammability hazard.

TestOxymaPure®HOBt
Hazard ClassificationNot fall in to criteria of hazardous compounddesensitized explosive solid 4.1
ARC pressure release61bar178 Bar
DSC exothermic decomposition134 °C (ΔDH about -2500 kJ/kg)strong exothermic decomposition above 147 0C ΔDH about -2140 kJ/kg
Mechanical Sensitivity (Impact Testing)100 J, not sensitive 20J, sensitive to drop impact
Thermal Sensibility (Flame Ignition)No explosionslow burning 29 kg/min
Mechanical Sensitivity (Friction)with a force of 360 N on the friction pin as not sensitive to friction
MIE < 3mJ risk of dust explosion
Detonation testDetonation

Waste management

OxymaPure® can react with DIC in the absence of the carboxylic acid with formation of HCN in (7). The use of a wet scrubber or dimethyl trisulfide (DMTS) scavenger should be considered for large scale manufacturing (8)

On the other hand, OxymaPure® does not react with TBEC rendering HCN (9)

 

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